Prof Graeme Hanson
Prof Graeme Hanson

Contact Details

Centre for Advanced Imaging
Building 60
Brisbane, QLD, 4072
Email: graeme.hanson@cai.uq.edu.au
Telephone: (+61) 7 3365 3242
Fax: (+61) 7 3365 3833
 

Graeme Hanson's Research Group

  • Group leader

Prof Graeme Hanson, BSc(Hons), PhD

Group leader, Centre for Advanced Imaging
 

Career Profile

Academic Qualifications and Awards

  • Ph.D., 1984, La Trobe University.
  • B.Sc. (Hons.), 1978, La Trobe University.
  • Fellow Royal Australian Chemical Institute
  • Chartered Chemist Royal Australian Chemical Institute
  • German Chemical Society Lecturer, 2007

Appointments Held

  • Visiting Scientist, Inorganisch-Chemisches Institute, University Heidelberg, 2008
  • Treasurer, Society Biological Inorganic Chemistry (2007-2011)
  • Vice President, Asia Pacific EPR Society (2006-)
  • Associate Editor- Applied Magnetic Resonance (2004-)
  • Professorial Research Fellow, Centre for Advanced Imaging, The University of Queensland (2003-)
  • Principal Research Fellow, CMR, UQ (2000-2003)
  • Director and Treasurer, Australian and New Zealand Magnetic Resonance Society (1996-2004)
  • Senior Research Fellow, CMR, UQ (1995-1999)
  • Research Fellow, CMR, UQ (1990-1994)
  • Lecturer Department of Chemistry, UQ (1987-1989)
  • Research Fellow, Dept. of Physics, Monash University (1985-1986)
  • Research Fellow, Harvard University, (1983-1984)

Professional Affiliations

  • International EPR Society
  • Asia Pacific EPR Society
  • Australian and New Zealand Magnetic Resonance Society
  • Society for Biological Inorganic Chemistry
  • Royal Australian Chemical Institute

Research Interests

Through a unique synergistic approach involving both theoretical and experimental aspects of continuous wave and pulsed EPR spectroscopy, I have undertaken the geometric and electronic structural characterisation of the metal binding sites in metalloproteins and transition metal ion complexes. The development of computer simulation software suites (Xsophe-Sophe-XeprView, MoSophe, and iResonanz) has and will continue to ensure that my group is the world leader in this area and their application to the characterisation of active sites in metalloenzymes (DMSO reductase, DMS dehydrogenase, purple acid phosphatase, metallohydrolases, soxAX and beta amyloid), model transition metal ion complexes and metallo-drugs has provided many ground-breaking and novel insights into their reactivity.

Representative and Recent Publications

As of November, 2009 I have published 131 scholarly articles in internationally recognised journals or book series, presented 159 papers at various scientific conferences and have 5 patent applications and 28 book reports, software manuals and other publications. I have coedited two volumes (28, 29) of Biological Magnetic Resonance published in 2009 and have written two chapters in each volume. The five patents relate to the computer simulation of continuous wave EPR spectra leading to the commercialisation of the XSophe-Sophe-XeprView and Molecular Sophe computer software suites through Bruker Biospin Germany.

  • Hadler, K.S.; Nataša Mitić, N.; Fernanda Ely, F.; Hanson, G.R.; Gahan, L.R.; Larrabee, J.A.; Ollis, D.; Schenk, G. “Reaction Mechanism of the Promiscuous Bioremediator Glycerophosphodiesterase from Enterobacter aerogenes” J. Am. Chem. Soc., 2009, 131, 11900-11908. DOI: 10.1021/ja903534f. (IF: 8.091)
  • Hanson, G.R. “Multifrequency EPR Spectroscopy: A Toolkit for the Characterization of Mono- and Binuclear Metal Ion Centers in Complex Biological Systems” in Comba, P. (Ed.) Structure and Function, 2009, Springer, New York, DOI: 10.1007/978-1-4419-1139-1.
  •  “Metals in Biology: Applications of High Resolution EPR to Metalloenzymes”, Biological Magnetic Resonance, 2009, 29, Hanson, G.R.; Berliner, L.J. (Eds), Springer, New York, DOI: 10.1007/978-1-4419-1139-1. http://www.springer.com/biomed/book/978-1-4419-1138-4
  • Hanson, G.R.; Lane, I. “Dimethylsulfoxide (DMSO) Reductase a Member of the DMSO Reductase Family of Molybdenum Enzymes” in Hanson, G.R.; Berliner, L.J. (Eds.) “Metals in Biology: Applications of High Resolution EPR to Metalloenzymes”, Biological Magnetic Resonance, 2009, 29, Springer, New York, DOI: 10.1007/978-1-4419-1139-1.
  • Smith, S.; Hadler, K.S; Schenk, G.; Hanson, G.R.; Mitic, N. “Binuclear Manganese Dependent Enzymes” in Hanson, G.R.; Berliner, L.J. (Eds.) “Metals in Biology: Applications of High Resolution EPR to Metalloenzymes”, Biological Magnetic Resonance, 2009, 29, Springer, New York, DOI: 10.1007/978-1-4419-1139-1.
  • Hanson, G.R.; Paul Jensen, P.; McMurtrie, J.; Rintoul, L.; Micallef, A.S. “Halogen Bonding Between an Isoindoline Nitroxide and 1,4-Diiodotetrafluorobenzene”, Chem. Eur. J., 2009, 16, 4156-4164. (IF: 5.454)
  • Bos, R.; Tonkin, S.A.; Hanson, G.R.; Hindson, C.M.; Lim, KF.; Barnett, N.W., “In Search of a Chemiluminescence 1,4-Dioxy Biradical”, J. Am. Chem. Soc., 2009, 131, 2770-2771. (IF: 8.091)
  • Drew, S,C.; Noble, C.J.; Hanson, G.R.; Masters, C.L.; Barnham, K.J. “The pleomorphic Cu2+ coordination of Alzheimer’s amyloid-β peptide – isotopic labeling studies using EPR spectroscopy”, J. Am. Chem. Soc., 2009, 131, 1195-1207. (IF: 8.091)
  • Drew, S.C.; Hanson, G.R.; “Determination of the metal-dithiolate fold angle in mononuclear molybdenum(V) centers by EPR spectroscopy”, Inorg. Chem. 2009, 48, 2224-2232. (IF: 4.147)
  • Mitić, N.; Noble, C.J.; Gahan, L.R.; Hanson, G.R.; Schenk, G. “Metal Ion Mutagenesis – Conversion of a Purple Acid Phosphatase from Sweet Potato to a Neutral Phosphatase with the Formation of an Unprecedented Catalytically Competent MnIIMnII Active Site”, J. Am. Chem. Soc., 2009, 131, 8173-8179. DOI: 10.1021/ja900797u. (IF: 8.091)
  • Kappler, U.; Bernhardt, P.V.; Kilmartin, J.; Riley, M.J.; Teschner, J.; McKenzie, K.J.; Hanson, G.R. “SoxAX Cytochromes – A New Type of Heme Copper Protein Involved in Bacterial Energy Generation from Sulfur Compounds”, J. Biol. Chem., 2008, 283, 22206-22214. (IF: 5.52)
  • Smith, S.J.; Noble, CJ.; Palmer, R.C.; Hanson, G.R.; Schenk, G.; Gahan, L.R; Riley, MJ. “Structural and Spectroscopic Studies of a Model for Catechol Oxidase”, J. Biol. Inorg. Chem., 2008, 13, 499-510. (IF: 3.6)
  • Comba, P.; Gahan, L.R.; Haberhauer, G.; Hanson, G.R.; Noble, C.J.; Seibold, S.; van den Brenk, A.L. “Copper(II) coordination chemistry of Westiellamide and its imidazole, oxazole and thiazole analogues”, Chem. Eur. J., 2008, 14, 4393-4403. (IF: 5.454)
  •  “High Resolution EPR: Applications to Metalloenzymes and Metals in Medicine”, Biological Magnetic Resonance, 2009, 28, Hanson, G.R.; Berliner, L.J. (Eds), Springer, New York. http://www.springer.com/biomed/book/978-0-387-84855-6
  • Hanson, G.R.; Noble, C.J.; Benson, S. “Molecular Sophe, An Integrated Approach to the Structural Characterization of Metalloproteins, The Next Generation of Computer Simulation Software” in Hanson, G.R.; Berliner, L.J. (Eds.) “High Resolution EPR: Applications to Metalloenzymes and Metals in Medicine”, Biological Magnetic Resonance, 2009, 28, 105-174.
  • Schenk, G.; Peralt, G.A.; Batista, S.C.; Bortoluzzi, A.J.; Szpoganicz; Dick, A.; Herrald, P.; Hanson, G.R.; Szilagyi, R.K.; Riley, M.J.; Gahan, L.R.; Neves, A. “Probing the Role of the Divalent Metal Ion in Uteroferrin using Metal Ion Replacement and a Comparison to Isostructural Biomimetics”, J. Biol. Inorg. Chem., 2008, 13, 139-155. (IF: 4.147)
  • Mitic, N.; Schenk, G.; Hanson, G.R. “Binuclear Non Heme Enzymes” in Hanson, G.R.; Berliner, L.J. (Eds.) “High Resolution EPR: Applications to Metalloenzymes and Metals in Medicine”, Biological Magnetic Resonance, 2009, 28, 269-396.
  • Drew, S.C; Hill, J.P.; Lane, I.; Hanson, G.R.; Gable, R.W.; Young, C.G. “Synthesis, Structural Characterization and Multifrequency Electron Paramagnetic Resonance Studies of Mononuclear Thiomolybdenyl Complexes”, Inorg. Chem., 2007, 46, 2373-2387. (IF: 4.147)
  • Drew, S.C; Young, C.G.; Hanson, G.R. “A Density Functional Study of the Electronic Structure and Spin Hamiltonian Parameters of Mononuclear Thiomolybdenyl Complexes”, Inorg. Chem., 2007, 46, 2388-2397. (IF: 4.147)

View a list of publications on Graeme Hanson's  UQ eSpace profile 

 

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