Braskie MN, Jahanshad N, Stein JL, Barysheva M, McMahon KL, deZubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM.

Common Alzheimer's Disease Risk Variant Within the CLU Gene Affects White Matter Microstructure in Young Adults. Journal of Neuroscience, 31:6764-6770, 2011


Distinct brain differences in early adulthood for those that carry the Alzheimer’s disease risk gene.


An international collaboration between the Centre for Advanced Imaging, Queensland Institute of Medical Research and the Laboratory of NeuroImaging at the University of California, Los Angeles has revealed a correlation between white matter integrity in healthy young adults and a gene that has been linked to risk of late onset Alzheimer’s. (Braskie MN, Jahanshad N, Stein JL, Barysheva M, McMahon KL, deZubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Journal of Neuroscience, 31:6764-6770, 2011.)

People with the C allele of the Clusterin gene have a 1.6% greater chance of developing late onset Alzheimer’s compared with the T allele. Even in adults with a mean age of 24 years, the C allele was associated with lower white matter integrity in multiple brain regions. These included several that have been previously observed to deteriorate in Alzheimer’s.

The distinct profile of lower white matter integrity may increase vulnerability to developing AD later in life. The evidence of early brain differences may offer a target for intervention decades before symptom onset.


Regions where Clusterin-C is associated with lower FA (FDR critical p vale =0.023).

Left hemisphere is displayed on the right. ILF = inferior longitudinal fasciculus; SLF = superior longitudinal fasciculs; IFO = inferior fronto-occipital fasciculus.
 

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